Basic Information
VIS ID
TVIS44002901
Fusion event
HTLV-1-ADAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
952750/913113 (Hg38)
End
952750/913113 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
ADAP1
miRNAs that regulate target gene
hsa-mir-8070 ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-4679 ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-224-5p ; hsa-mir-5680
Nearest miRNA
hsa-mir-10399/Downstream/109820;
Nearest TSS
ENST00000635602/Upstream/7497; ENST00000462453/Downstream/7776;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/3582, chr7-CpG: 18/Downstream/6974
Upstream sequence
attaaactttgtcttgagacggagtctccccacgttgcccaggctggtgttgaactcctggctcaagcaaccctcccacctcggcctcccagagtgctgc
Downstream sequence
aatgacaggcatgagccccggtgcccggccTTCTTTTGtattaactggaattcgtgtgcaaaggctgctggcctcctccccttccttttttttttttttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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