Basic Information
VIS ID
TVIS44002928
Fusion event
HTLV-1-NMT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
43165837/45088469 (Hg38)
End
43165837/45088469 (Hg38)
Orient
+
Location type
Intronic
Target gene
NMT1
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-186-5p ; hsa-mir-23b-3p ; hsa-mir-30d-5p
Nearest miRNA
hsa-mir-1180/Upstream/153788; hsa-mir-10226/Downstream/25898;
Nearest TSS
ENST00000595228/Upstream/26790; ENST00000588455/Downstream/5162;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/26980, chr17-CpG: 65/Downstream/32441
Upstream sequence
TTTTGGAGTTTTGGTTTGATTTTATTTTTCCTGAGGAATTTGCAAATGAGTAACCTTGCTACATTCTTCACAGATAGTGGCACTTGGGAAAGAGGCAGAT
Downstream sequence
TGAggctgggcgcagtggctcacgcctgtaatcccagcactttgggaggtcgaggcaggcggatgacctgaggtcaggagttcgagaccagcctggccaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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