Basic Information
VIS ID
TVIS44002936
Fusion event
HTLV-1-ABCC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
16112854/16018997 (Hg38)
End
16112854/16018997 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16A
Target gene
ABCC1
miRNAs that regulate target gene
hsa-mir-345-5p ; hsa-mir-7-5p ; hsa-mir-134-5p ; hsa-mir-9-5p ; hsa-mir-1-3p ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-615-3p ; hsa-mir-339-5p ; hsa-mir-125b-5p ; hsa-mir-23b-3p ; hsa-mir-16-5p ; hsa-mir-1291 ; hsa-mir-3180-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-361-3p ; hsa-mir-1825 ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-5195-3p ; hsa-mir-5582-3p ; hsa-mir-145-5p ; hsa-mir-199a-5p ; hsa-mir-199b-5p ; hsa-mir-224-5p
Nearest miRNA
hsa-mir-1225/Upstream/375625; hsa-mir-11401/Downstream/281162;
Nearest TSS
ENST00000527434/Upstream/4457; ENST00000576557/Downstream/57177;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/68927, chr16-CpG: 30/Downstream/204382
Upstream sequence
aaggccaaggctagaggatcgcttgagcccaggggtCACCCCATTTTGGATCCCTGGCTGGTGCCTGACACAGAAGAGAGGGGCTCATGAGTCAGTGGCT
Downstream sequence
GTTATATGTATTGTGTATCAGTGTGTGTAAGTGTGTGGCAGCCGAGTGTCCCTGTTTGTCAAATGTTGGGCTATTCTTTTTTGTCTTTTGTTTGttgttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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