Basic Information
VIS ID
TVIS44002937
Fusion event
HTLV-1-RAP1GAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2781102/2877808 (Hg38)
End
2781102/2877808 (Hg38)
Orient
-
Location type
Intronic
Target gene
RAP1GAP2
miRNAs that regulate target gene
hsa-mir-652-3p ; hsa-mir-149-5p ; hsa-mir-222-3p ; hsa-mir-181b-5p ; hsa-mir-6085 ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-5010-5p ; hsa-mir-615-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-765 ; hsa-mir-6738-5p ; hsa-mir-4731-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4537 ; hsa-mir-637 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-6793-3p
Nearest miRNA
hsa-mir-1253/Upstream/129626; hsa-mir-10226/Downstream/2091894;
Nearest TSS
ENST00000595228/Upstream/81326; ENST00000574515/Downstream/88087;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/23164, chr17-CpG: 35/Downstream/170875
Upstream sequence
ccactgtacttcagcctgggtgacagagAATTAAATGAATGCCTGAAATTTGGTTTTAGTGAATGAATGCTTgaaatttggttctcatggtgagggtgac
Downstream sequence
aggaagccatttcaaggccttagatagggggctcatatgatcaggttgacattttggaaggtccctgtagctcctgggggagacagtttgggagtgggac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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