Basic Information
VIS ID
TVIS44002940
Fusion event
HTLV-1-DPYSL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
26388844/26531328 (Hg38)
End
26388844/26531328 (Hg38)
Orient
-
Location type
Intronic
Target gene
DPYSL2
miRNAs that regulate target gene
hsa-mir-19a-3p ; hsa-mir-425-5p ; hsa-mir-320a ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-17-5p ; hsa-mir-224-5p ; hsa-mir-452-5p ; hsa-mir-181c-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-944 ; hsa-mir-548t-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548az-5p ; hsa-mir-125a-3p ; hsa-mir-3665 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-657 ; hsa-mir-539-5p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-548e-5p ; hsa-mir-4724-3p ; hsa-mir-6782-3p ; hsa-mir-548n
Nearest miRNA
hsa-mir-124-1/Upstream/1185854; hsa-mir-10400/Downstream/517525;
Nearest TSS
ENST00000518652/Upstream/17236; ENST00000493789/Downstream/45734;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/16014, chr8-CpG: 147/Downstream/45528
Upstream sequence
AGCAGAGGAAATTGAGGAGGCCCACAACGGAGGTCTGAAGAGAACACAGGGGCATTAATCCCTGTGGAAGGGCAGCTCGGGGGCTCATGGAAGTTCCCAC
Downstream sequence
AGGCCCAGCAGTAACACTCCTGGGTATGCAGAGATCACCTCTCAACCTCTGCAACCAGCTGGAAGTgagctcagaagagattttagggctggagatagag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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