Basic Information
VIS ID
TVIS44002963
Fusion event
HTLV-1-PHKA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.13
Reference genome
GRCh37/hg19
Start
18975577/18957459 (Hg38)
End
18975577/18957459 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHKA2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-149-5p
Nearest miRNA
hsa-mir-3690-1/Upstream/1531505; hsa-let-7f-2/Downstream/1059629;
Nearest TSS
ENST00000429181/Upstream/30979; ENST00000417819/Downstream/27139;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/281980, chrX-CpG: 130/Downstream/26426
Upstream sequence
TTTAAGTATGGCAATGGAGGAGGGAGAAAAAGGCTGCCCTGTCTGATGCCATTCTGCAAGCTAAACATAAACACAGGCAAATGCAGACCACAGGAGGATG
Downstream sequence
GTGGGGAGATTGGTCCAAGCCAAGCCTATGGTTTCAGATGTGATCATTTTAACCATATGTTGCTTTCCAATCTTTGAAAAACACTATTTAGCTATATCTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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