Basic Information
VIS ID
TVIS44002989
Fusion event
HTLV-1-USH1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17547230/17525683 (Hg38)
End
17547230/17525683 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
USH1C
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-210/Upstream/1556062; hsa-let-7a-2/Downstream/862104;
Nearest TSS
ENST00000527297/Upstream/4721; ENST00000428619/Downstream/7827;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/48604, chr11-CpG: 30/Downstream/18536
Upstream sequence
ctcttaagtgggaaagcagggctggaactgggatctgAGTAACGGTGGCACCTGCATGCTTAAGCCCCGTGTGGCCCAGTGTCTGTTCGGAATTCCCTGT
Downstream sequence
CTGCCTCTTAAGGAAGCCAACAAGTTAATAAGTGACAAGAGAGCTGTGACAGAGATGACCAGCCAAACAGGCTCCTTTTGCAGTGACTCAAGGGCCCACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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