Basic Information
VIS ID
TVIS44002990
Fusion event
HTLV-1-NTM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
131420773/131550879 (Hg38)
End
131420773/131550879 (Hg38)
Orient
-
Location type
Intronic
Target gene
NTM
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-340-5p ; hsa-mir-501-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p
Nearest miRNA
hsa-let-7a-2/Upstream/884076; hsa-mir-4697/Downstream/2347625;
Nearest TSS
ENST00000527297/Upstream/10012; ENST00000416661/Downstream/22721;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/634140, chr11-CpG: 16/Downstream/139583
Upstream sequence
aagctaagatcatgccactgcattttagcctgggcaatagagcaataccctgtctatttaaaaaaaTACCCTCAAAAAACAGCCCTTAACAGACACTGTT
Downstream sequence
CTGCCTCTTTTCTACACGAAGTTACCGAGACTTCCAAGTGTTACGTAGTTTGTTAATGCTGTTGCCCTGCTGGCTGTGGATGAGCCTAGATGCAGACCCG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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