Basic Information
VIS ID
TVIS44002994
Fusion event
HTLV-1-UBE2L3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
21932208/21577919 (Hg38)
End
21932208/21577919 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE2L3
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-423-5p ; hsa-mir-93-5p ; hsa-mir-125a-5p
Nearest miRNA
hsa-mir-1286/Upstream/543647; hsa-let-7a-3/Downstream/75062;
Nearest TSS
ENST00000624155/Upstream/10189; ENST00000425975/Downstream/52093;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/9493, chr22-CpG: 159/Downstream/50578
Upstream sequence
GGCAGAGCGGGGAACATTCTCTTTTGACAGCCCTTATCCCAGCAGGCACATCTGCAACCAAAGCAGGTGCTAATGTCAAAGGGCTCATGGGCTAATGTCA
Downstream sequence
GGGCTCATGTGATGCTCCATCTTTCTGAGAGGAGACCACCTGACTCACGGTGAGGAAGAGGGTGTAACTCAGAGGTTGAATAGCCTCTGAACCCGTCTGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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