Basic Information
VIS ID
TVIS44002995
Fusion event
HTLV-1-ROBO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
76209159/76160008 (Hg38)
End
76209159/76160008 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROBO2
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-342-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6844 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-8084
Nearest miRNA
hsa-let-7g/Upstream/421645; hsa-mir-12124/Downstream/3347879;
Nearest TSS
ENST00000440867/Upstream/253206; ENST00000475034/Downstream/151088;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/252851, chr3-CpG: 63/Downstream/879339
Nearby gene
ZNF717(-374425) ;
Upstream sequence
tcaggactgtgaggtagatgcctcatgattttccatcaaaactcttacaaaattgcctgtacttgatgaaaggaatgagccaggaacgttgttgtggtgg
Downstream sequence
agaaagactccctggtaaagctttccaaggtgtttttctgtaaagctttggctaactttcttaaaacactctcataataagcaaatgttattttttggct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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