Basic Information
VIS ID
TVIS44003021
Fusion event
HTLV-1-SLC24A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
20163178/20163180 (Hg38)
End
20163178/20163180 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
SLC24A2
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-6083 ; hsa-mir-4789-5p ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-340-5p ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-4775 ; hsa-mir-29a-5p ; hsa-mir-590-3p ; hsa-mir-410-3p ; hsa-mir-4672 ; hsa-mir-6768-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4474-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3922-5p ; hsa-mir-3142 ; hsa-mir-1245b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1589801; hsa-let-7a-1/Downstream/247968;
Nearest TSS
ENST00000422679/Upstream/237086; ENST00000604036/Downstream/200389;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/228351, chr9-CpG: 167/Downstream/457245
Nearby gene
MLLT3(-178485) ;
Upstream sequence
taccctctctcacaactcctattcaacatagtgttggaagttctggccagggcaattaggcaggagaaggaaacaaagggtattcaactaggaaaagagg
Downstream sequence
aagtcaaattgtccctgtttgcagatgacatgattttatatctagaaaaccccatcgtctcagtccaaaatctccttaagctgataagcaacttcagcaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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