Basic Information
VIS ID
TVIS44003045
Fusion event
HTLV-1-ZBTB14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
5295917/5295918 (Hg38)
End
5295917/5295918 (Hg38)
Orient
-
Location type
UTR5
Target gene
ZBTB14
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-6718/Upstream/1410486; hsa-mir-1-2/Downstream/544777;
Nearest TSS
ENST00000575820/Upstream/216; ENST00000579113/Downstream/122;
Nearest CpG islands
chr18-CpG: 182/Target, None/Upstream, None/Downstream
Upstream sequence
CCTGGCACAGGCACAGACACTGCCGTGGGTTCCCCGCGCTCGCTAGCAAACGCAGGCCGGGACCGGAGGGGCTCGGGGCGCGGGGGCACGGTGGGTGGCA
Downstream sequence
GTGTGTTTTGGATTTTTTTTTGGAGTTTGGGGAGGGGGCGGGGTGGGGGAAATCGTGCACGTCCCTGATGGTAGCAGCCCTCCTCCTGCACGAGCACAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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