Basic Information
VIS ID
TVIS44003057
Fusion event
HTLV-1-CMKLR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
108732738/108338961 (Hg38)
End
108732738/108338961 (Hg38)
Orient
-
Location type
Intronic
Target gene
CMKLR1
miRNAs that regulate target gene
hsa-mir-629-3p ; hsa-mir-4279 ; hsa-mir-627-3p ; hsa-mir-6758-3p ; hsa-mir-548m ; hsa-mir-7850-5p ; hsa-mir-4529-3p ; hsa-mir-4520-2-3p ; hsa-mir-8058 ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-3156-3p ; hsa-mir-9-5p ; hsa-mir-532-3p ; hsa-mir-4301 ; hsa-mir-6777-3p ; hsa-mir-551b-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-511-5p ; hsa-mir-6873-3p ; hsa-mir-502-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6830-3p ; hsa-mir-4778-3p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5088-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p
Nearest miRNA
hsa-let-7i/Upstream/3747245; hsa-mir-1178/Downstream/296849;
Nearest TSS
ENST00000382841/Upstream/18299; ENST00000552758/Downstream/352;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/209265, chr12-CpG: 66/Downstream/175964
Upstream sequence
TAAACAATGAACATGCATTACTTTTGACATCTGAAAATAATAACAAAACTCTTCCTTTTAACAAATATGAAATTATAAAAAGAAACAAACTTTTCTCTCT
Downstream sequence
GTTAGTATTCATTCCCCTTCCCTGGCCCCCCTCAGAAGACACCCAAGGCAAGTGTGTGATGATACCTTCCCTCTGGTCTCTGCCCGGAAGGTCTTCCTGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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