Basic Information
VIS ID
TVIS44003061
Fusion event
HTLV-1-ATP11A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
113475235/112820921 (Hg38)
End
113475235/112820921 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP11A
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-769-5p ; hsa-mir-484 ; hsa-mir-197-3p ; hsa-mir-92a-3p ; hsa-mir-4777-5p ; hsa-mir-523-5p ; hsa-mir-526a ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-337-3p ; hsa-mir-202-5p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-617 ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-211-3p ; hsa-mir-5680 ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-1267/Upstream/2479892; hsa-mir-4502/Downstream/441999;
Nearest TSS
ENST00000623511/Upstream/35749; ENST00000459011/Downstream/15322;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/883, chr13-CpG: 38/Downstream/11600
Upstream sequence
GTAGGTACAGCATTGTGTGTTAAACAACACATCTCCCAGACACAGAAACACACTCACTGGGAAACTACTGCAAAGTGAATAGTTCCTGAAATGCTTAGCT
Downstream sequence
CCTTGTAAGTCTCCAGGAGCTACTGTTTTAAGAAAACCATTTGTGCACTTCTTAGCATGTGCTTGTTATCATTACCCATCAGCAGGCTAGGAGGTGCTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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