Basic Information
VIS ID
TVIS44003067
Fusion event
HTLV-1-CADM4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
44142456/43638304 (Hg38)
End
44142456/43638304 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CADM4
Nearest miRNA
hsa-mir-10395/Upstream/1287099; hsa-let-7e/Downstream/1015382;
Nearest TSS
ENST00000633603/Upstream/12333; ENST00000596627/Downstream/1535;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/18212, chr19-CpG: 112/Downstream/1059
Nearest cancer related gene
CADM4(TSG, No orient, 0)
Upstream sequence
CAAACCCTGGAGTGGGGAACATGTAACCGCACTCAACTTGCCAGAAACCCCTTCACGgtctgagctggcgttccctttcatgtcactgagttcaacatcc
Downstream sequence
tcactttacagaaagagaaacagaagcctggagagaggaaggtgtttaccattggctgcgatggcaaatggcaagagccaagatttaagcccaggccgcc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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