Basic Information
VIS ID
TVIS44003078
Fusion event
HTLV-1-ZSWIM5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
45507889/45042217 (Hg38)
End
45507889/45042217 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZSWIM5
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-4287 ; hsa-mir-4325 ; hsa-mir-4469 ; hsa-mir-452-3p ; hsa-mir-4685-3p ; hsa-mir-4713-5p ; hsa-mir-4793-3p ; hsa-mir-629-3p ; hsa-mir-6500-3p ; hsa-mir-6752-3p ; hsa-mir-6867-3p ; hsa-mir-7113-3p ; hsa-mir-942-5p
Nearest miRNA
hsa-mir-12136/Upstream/496665; hsa-mir-101-1/Downstream/6017620;
Nearest TSS
ENST00000473358/Upstream/27670; ENST00000626198/Downstream/164339;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/30867, chr1-CpG: 150/Downstream/163450
Upstream sequence
atggctcaggataaattcctacatgtagaattcctggatcacatgggatgaacatattttaaggcttttgataagaagaaatacccttcagaaagactaa
Downstream sequence
gtatttacactcctataagtagtaaatgagagtacctagctccatgtaacctctcccacaccagaaactaattatcttaattaaaaacacctgaccattt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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