Basic Information
VIS ID
TVIS44003087
Fusion event
HTLV-1-NRIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
16434132/15061811 (Hg38)
End
16434132/15061811 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
NRIP1
miRNAs that regulate target gene
hsa-mir-140-3p ; hsa-mir-590-3p ; hsa-mir-24-3p ; hsa-mir-615-3p ; hsa-mir-15b-5p ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-190a-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-5580-3p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-4766-3p ; hsa-mir-651-5p ; hsa-mir-2053 ; hsa-mir-3192-3p ; hsa-mir-1258 ; hsa-mir-215-3p ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-3151-3p ; hsa-mir-1265 ; hsa-mir-2392 ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-1229-3p ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-3908 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-8485 ; hsa-mir-562 ; hsa-mir-548n ; hsa-mir-548as-3p
Nearest miRNA
hsa-mir-10396a/Upstream/1337537; hsa-let-7c/Downstream/1477278;
Nearest TSS
ENST00000624081/Upstream/47381; ENST00000449746/Downstream/2994;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/678046, chr21-CpG: 171/Downstream/2364
Upstream sequence
AGAACATGAGCTTTTGAGTTTCTTACATTCTTTACGTTTTAAAATTAAAAGCCAAATTCCTTTAACCTCATATATCCTAAGCCACTCTGATTTAAAATTA
Downstream sequence
CTTCTATGTCATTGTCTTCTAGCATTGGTCTGCAATAGAATCTGTGCAATTAACAATAATCTTCTTCCCTCTGATCTTTCTAGAGTCAAGGATGGCATAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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