Basic Information
VIS ID
TVIS44003088
Fusion event
HTLV-1-FAM135A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
71136618/70426915 (Hg38)
End
71136618/70426915 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
FAM135A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-let-7d-5p ; hsa-mir-92a-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-548j-5p ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548ay-5p ; hsa-mir-548bb-5p ; hsa-mir-548n ; hsa-mir-1277-5p ; hsa-mir-374a-5p ; hsa-mir-1468-3p ; hsa-mir-548p ; hsa-mir-6509-5p ; hsa-mir-331-5p ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-374c-3p
Nearest miRNA
hsa-mir-10398/Upstream/13036703; hsa-mir-10524/Downstream/950045;
Nearest TSS
ENST00000381078/Upstream/387; ENST00000425415/Downstream/1428;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12798, chr6-CpG: 47/Downstream/139923
Upstream sequence
cttttagaatggacagtaaacctgcctgacttttttcctggagggaggctttatctgtattatacagaacagtagacaaatctgccctttgttctagtat
Downstream sequence
aagacactatctctgacttctaagattgttcattatacaaacatccgtgaaaagatagtctggaacaaaggctgtctatgtctctgcttgtgagacgtgt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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