Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene592613585917143059208587591427485915503959182288591928945917106859177350591933385919635259197645592006155917977859182270591775455917933159151864591531405915820159158897592014685920169759179385591795455915466859154817591929485919309759202053
Basic Information
VIS ID
TVIS44003094
Fusion event
HTLV-1-DTX4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
58969526/59202053 (Hg38)
End
58969526/59202053 (Hg38)
Orient
+
Location type
Intronic
Target gene
DTX4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-586 ; hsa-mir-5011-5p ; hsa-mir-598-3p ; hsa-mir-448 ; hsa-mir-6715b-3p ; hsa-mir-6715a-3p ; hsa-mir-6771-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-5003-5p ; hsa-mir-4709-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p
Nearest miRNA
hsa-mir-129-2/Upstream/1560767; hsa-let-7a-2/Downstream/393024;
Nearest TSS
ENST00000527297/Upstream/7161; ENST00000313940/Downstream/10898;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/28474, chr11-CpG: 34/Downstream/358611
Upstream sequence
AGCTCATTCCTCCCTGCACTCACTGCCTTCCAAACCACTAGACTCCTCTTCTAACCCTGCCACTGCCAACATAGATAAGACTTCATCTTTTACCTGCTAC
Downstream sequence
CAGGTTAGTTTCAAACAGTTTCTAGAATCAAGCTTTTTGTGTGTAAAAGAAATAAAATGAAGAAACAACAAAGTGCACTCTTCTCAGCTTGACATATAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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