Basic Information
VIS ID
TVIS44003103
Fusion event
HTLV-1-MGAT4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99253660/98637197 (Hg38)
End
99253660/98637197 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
MGAT4A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-409-3p ; hsa-mir-376a-5p ; hsa-mir-4423-3p ; hsa-mir-376a-2-5p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-564 ; hsa-mir-3622a-5p ; hsa-mir-5582-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/1838844; hsa-mir-10b/Downstream/2672253;
Nearest TSS
ENST00000437798/Upstream/20800; ENST00000496794/Downstream/26276;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/28338, chr2-CpG: 150/Downstream/93222
Upstream sequence
tcaggggttcaagaccagcctgggcaacacagtgagacctcgtcgctacaaaaaaattaaaaaattagccaggcatggtggtatgtacctgtagtcccag
Downstream sequence
ctactcaggaagctaaggtgagaggattgcttgagtttagcctggaaggtctcatctacagtgagccgtgactgtgccactgcactccagcctgggtaac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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