Basic Information
VIS ID
TVIS44003105
Fusion event
HTLV-1-ZBTB11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
101377703/101658859 (Hg38)
End
101377703/101658859 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZBTB11
miRNAs that regulate target gene
hsa-mir-877-5p ; hsa-mir-548i
Nearest miRNA
hsa-let-7g/Upstream/1694461; hsa-mir-12124/Downstream/1865174;
Nearest TSS
ENST00000440867/Upstream/69110; ENST00000609682/Downstream/1064;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/84091, chr3-CpG: 117/Downstream/17273
Upstream sequence
ggggtgaggcataaaagactacaccctgggtatagtgtatactgcttaagtaatgggtacaccaaaatttggaaaacactactaaaaaacttacccatgt
Downstream sequence
aaacaaacaccacctgttccccaaaaactattaaaatacagaaaGAAAAAAAATCTCATTGGTTCCAAAACTGTTTTTTAATAAAAATACTAAGTCAggc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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