Basic Information
VIS ID
TVIS44003118
Fusion event
HTLV-1-KIAA1109 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
GRCh37/hg19
Start
123127789/122206634 (Hg38)
End
123127789/122206634 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIAA1109
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-219a-2-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-410-3p ; hsa-mir-497-3p ; hsa-mir-92b-3p ; hsa-mir-873-5p ; hsa-mir-4528 ; hsa-mir-5589-3p ; hsa-mir-190a-3p ; hsa-mir-340-5p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-944
Nearest miRNA
hsa-mir-12113/Upstream/7549780; hsa-mir-1305/Downstream/3300625;
Nearest TSS
ENST00000502981/Upstream/9885; ENST00000482114/Downstream/2540;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/54013, chr4-CpG: 45/Downstream/172618
Upstream sequence
ctgaatatgtaaaatatcttttacaaaaatatataatacatgataatatatataacacaaaaatttggaaagagtataaatatccaactataaaaaatgg
Downstream sequence
ttaagtaggtcctgacaaatctcattaatgagctattatgccaaatttatgtaaacgtgtgaaataacacggaaaaatatttgagttcagtgaaagaagc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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