Basic Information
VIS ID
TVIS44003130
Fusion event
HTLV-1-CSMD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
4770996/4913474 (Hg38)
End
4770996/4913474 (Hg38)
Orient
-
Location type
Intronic
Target gene
CSMD1
miRNAs that regulate target gene
hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-567 ; hsa-mir-5011-5p ; hsa-mir-4704-5p ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-1277-5p ; hsa-mir-338-5p ; hsa-let-7c-3p ; hsa-mir-10b-5p
Nearest miRNA
hsa-mir-3674/Upstream/2836834; hsa-mir-10400/Downstream/1708650;
Nearest TSS
ENST00000518652/Upstream/881374; ENST00000522905/Downstream/81227;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1891048, chr8-CpG: 256/Downstream/77972
Nearest cancer related gene
CSMD1(TSG, No orient, 0)
Upstream sequence
attgctttttcttgattgttttcctaattcctagtaaagtgcttggacactcagtgaatatttcttcactgaatgCTATTAATGGCCATTGTCCATCAGC
Downstream sequence
ATCAAATAGAGAATGAAAACTACCCCCATATGTCTTATTTTAAACAGAAGCCCTGCCCTCAAAGAGCTCTACAGGGGAACGCCACCAACATATGCGTCCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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