Basic Information
VIS ID
TVIS44003161
Fusion event
HTLV-1-SYT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
79329881/78936101 (Hg38)
End
79329881/78936101 (Hg38)
Orient
+
Location type
Intronic
Target gene
SYT1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-335-5p ; hsa-mir-8064 ; hsa-mir-8485 ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-202-3p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-4678 ; hsa-mir-4699-3p ; hsa-mir-5683 ; hsa-mir-711 ; hsa-mir-7162-3p ; hsa-mir-98-5p
Nearest miRNA
hsa-let-7i/Upstream/9351278; hsa-mir-1178/Downstream/483156;
Nearest TSS
ENST00000382841/Upstream/67329; ENST00000547046/Downstream/27934;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/131481, chr12-CpG: 198/Downstream/753650
Nearest cancer related gene
SYT1(OG, No orient, 0)
Upstream sequence
AGATACAGTAATCTTATAGCCAAGGCAAGCCTTTGGATATAAGATTTTTAAAAGCTTGGAGaaaattattttattataataaaatcaattattGAGATCC
Downstream sequence
ACTGTATTTATGTCACTTCTTTTAGAGTTACATAGAAATTTTAATCTTTGTCTACAAAGAATTACACTTTAAAGGAACAATTTCAGTGTAGGAAAGGTTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate