Basic Information
VIS ID
TVIS44003168
Fusion event
HTLV-1-PARN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14663171/14569314 (Hg38)
End
14663171/14569314 (Hg38)
Orient
+
Location type
Intronic
Target gene
PARN
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-377-3p ; hsa-mir-8485 ; hsa-mir-521 ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-376a-2-5p
Nearest miRNA
hsa-mir-1225/Upstream/259943; hsa-mir-11401/Downstream/332194;
Nearest TSS
ENST00000527434/Upstream/4239; ENST00000570219/Downstream/15446;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/266096, chr16-CpG: 55/Downstream/60431
Upstream sequence
atatacaaatttaaaaaaaaaaaaGAATTTAAAAAAACGAAATGAAATGAGAAACAAGATTTCCATTATTTTCTTCAAGTTCACTACAGTGTAAGTCACA
Downstream sequence
GTAACAACCACCCTTTCTGCACACCTTCTACATGCCACACCCAACACCAAACAGCCTTATCAGCGCTGCTGCCCAACCAGGTGGAGATTATGATCTACAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate