Basic Information
VIS ID
TVIS44003180
Fusion event
HTLV-1-KLHL32 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
97443916/96996040 (Hg38)
End
97443916/96996040 (Hg38)
Orient
+
Location type
Intronic
Target gene
KLHL32
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6765-5p ; hsa-mir-1304-5p ; hsa-mir-1827 ; hsa-mir-4693-3p ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-3200-5p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-mir-10398/Upstream/5474303; hsa-mir-1202/Downstream/1028491;
Nearest TSS
ENST00000381078/Upstream/29031; ENST00000447886/Downstream/14159;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/71053, chr6-CpG: 53/Downstream/286780
Upstream sequence
TCCACCAAACTACTGTTGAACACTATTAAGTGAGGAAGTATTGAAACAGAGATAGCAAGAGAAATGAGGGGCCTCGAGTGGTGGGGACAAGTCAGCCTCT
Downstream sequence
TCTCCCTGCTTCCTTGGAAGCCCCTCTGACAGTGGGTACACATAAGTTACAGGGCCCAGCGTGGGCAGCCCTGGGCTGCGGGCCACTCTGTAGGTTCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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