Basic Information
VIS ID
TVIS44003185
Fusion event
HTLV-1-MINDY3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
15820661/15778662 (Hg38)
End
15820661/15778662 (Hg38)
Orient
-
Location type
UTR3
Target gene
MINDY3
miRNAs that regulate target gene
hsa-mir-183-5p
Nearest miRNA
hsa-mir-1265/Upstream/1342001; hsa-mir-107/Downstream/2066445;
Nearest TSS
ENST00000439456/Upstream/58537; ENST00000434386/Downstream/3673;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/58560, chr10-CpG: 29/Downstream/81418
Nearest cancer related gene
MINDY3(TSG, No orient, 0)
Upstream sequence
CATTTCATTGTAGAGGCTGATATATTACAAGCCGGAATCATTCAAACAATAAAAAAAGTGCCTCAATGAAATAAAACCCAAAAGTAGTTTATCAATAGTA
Downstream sequence
ACTGTGATACTTAATATACAAATGCTGTAGTATTGCGTTTGTAATTTGGTAAGTAAATGACCAAGTATCTGAATGCAAAAGTGATGAACTTTGATGAAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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