Basic Information
VIS ID
TVIS44003188
Fusion event
HTLV-1-C12orf66 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
64612644/64218864 (Hg38)
End
64612644/64218864 (Hg38)
Orient
-
Location type
Intronic
Target gene
C12orf66
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-640 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-6513-3p ; hsa-mir-5092 ; hsa-mir-8079 ; hsa-mir-1245a
Nearest miRNA
hsa-let-7i/Upstream/395137; hsa-mir-1178/Downstream/403645;
Nearest TSS
ENST00000382841/Upstream/71007; ENST00000540203/Downstream/3399;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/374243, chr12-CpG: 54/Downstream/3180
Upstream sequence
ACTACATAAATACAAAGAATACCTTTAAAAGCTTATCGGTAAACGCTAATCACCAGCATGTGAAACCAAGTAAAGTGAAACTACTCTAAGGAAGAGATAG
Downstream sequence
ACCATCAACACATTTCTTTCAAACAGTTCTCTTTTCTCAAAGCTCTCAGGAACCCAATCCTATCTGTTCACTATCTTGGTTTGGAATATCCAGCGGGGAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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