Basic Information
VIS ID
TVIS44003190
Fusion event
HTLV-1-TSC22D1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
45139904/44565768 (Hg38)
End
45139904/44565768 (Hg38)
Orient
-
Location type
Intronic
Target gene
TSC22D1
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-9-3p ; hsa-mir-590-3p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p
Nearest miRNA
hsa-mir-2276/Upstream/369568; hsa-mir-1267/Downstream/5430647;
Nearest TSS
ENST00000623511/Upstream/25735; ENST00000617014/Downstream/7577;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/128509, chr13-CpG: 216/Downstream/10161
Nearest cancer related gene
TSC22D1(TSG, No orient, 0)
Upstream sequence
GCAGCATCAGAACAGGTCATGCTTAACAGCTTCATATTTTTAAATTAAACTTTCTCTTTTATCGAattttttaaatcgagatggggactatgttgcctag
Downstream sequence
gttggtcttgaactcctgagctcaagtgatcctcctatcttggcctcccaaagtgatgcgattacaggtgtgaAATTAAACTTTCTAAACAAGAAATAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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