Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene144199918144150526144188370144149490144154267144140401144141800144129037144130294144130886144131993144123564144124470144139801144140200144105004144105173144123024144123173144147163144147173144152461
Basic Information
VIS ID
TVIS44003205
Fusion event
HTLV-1-STX11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
144473598/144152461 (Hg38)
End
144473598/144152461 (Hg38)
Orient
-
Location type
Intronic
Target gene
STX11
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-15b-3p ; hsa-mir-3185 ; hsa-mir-5188 ; hsa-mir-136-3p
Nearest miRNA
hsa-mir-10398/Upstream/3468578; hsa-mir-1202/Downstream/6950214;
Nearest TSS
ENST00000381078/Upstream/1935; ENST00000433557/Downstream/133240;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1581, chr6-CpG: 88/Downstream/34228
Upstream sequence
GGACTGGGTCATGGCTGGAAGAGCAAGGAAACTTTTGAGTTTAGTCATTTACTTGTCTTTGTAGGCAGCCTATTCTTCATTTGATACATGATTTAAAAAT
Downstream sequence
GTATGAATTTGAAAGGTATGGTTTTTAAAGTGCTTGAATGAACCATGTTTCATGTTATTTAATAACCATGTAAAACGAAATTCAGCTGATTATCACCCCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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