Basic Information
VIS ID
TVIS44003212
Fusion event
HTLV-1-ESCO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
19116831/21536870 (Hg38)
End
19116831/21536870 (Hg38)
Orient
+
Location type
Intronic
Target gene
ESCO1
miRNAs that regulate target gene
hsa-mir-143-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-3p ; hsa-mir-6787-3p ; hsa-mir-342-3p ; hsa-mir-5693 ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-1228-3p ; hsa-mir-216b-5p ; hsa-mir-216a-5p ; hsa-mir-1294 ; hsa-mir-3190-5p ; hsa-mir-3671 ; hsa-mir-3926 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-548s ; hsa-mir-5579-3p ; hsa-mir-607 ; hsa-mir-6849-3p ; hsa-mir-4652-3p ; hsa-mir-4778-5p
Nearest miRNA
hsa-mir-3156-2/Upstream/6706628; hsa-mir-1-2/Downstream/146648;
Nearest TSS
ENST00000575820/Upstream/22967; ENST00000579618/Downstream/24111;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/293482, chr18-CpG: 107/Downstream/63218
Upstream sequence
CTTCCTATTAGAAGCATCTAATCTGTGAATTGAAGAGAACTTCACTGCAATCTTAGCCAGGCAAGCCACTCTTCTTCCCAACCCTTAATTAGTACTCTCA
Downstream sequence
TCGGTAAAACAAAAGTGAGTATAGAGAAAAGGAACTCATGTTTACTTCCtatcaaccacttataggccagacattattcaaagcactttacaaatatttc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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