Basic Information
VIS ID
TVIS44003216
Fusion event
HTLV-1-ROBO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
76400914/76351763 (Hg38)
End
76400914/76351763 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROBO2
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-342-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6844 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-8084
Nearest miRNA
hsa-let-7g/Upstream/613400; hsa-mir-12124/Downstream/3156124;
Nearest TSS
ENST00000440867/Upstream/40667; ENST00000471893/Downstream/688123;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/444606, chr3-CpG: 63/Downstream/687584
Nearby gene
ZNF717(-566180) ;
Upstream sequence
TTGTTTGCCTTGTTCTTATAAATGTATGTATGTATAACCTCACATACATGTAAATATATGAGTTTTTCTTTAATTTACATTTTAGGAAGagatgacctgg
Downstream sequence
gtttaatttccacatctacctactattaactatgtgactttgagtaaattacttaacctacaatgctctcagtttcttcatttataaaagagggatatgc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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