Basic Information
VIS ID
TVIS44003220
Fusion event
HTLV-1-YKT6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44247565/44207966 (Hg38)
End
44247565/44207966 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
YKT6
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-124-3p ; hsa-mir-122-5p ; hsa-mir-1296-5p ; hsa-mir-708-5p ; hsa-mir-30d-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6737-5p ; hsa-mir-6802-5p ; hsa-mir-6742-5p ; hsa-mir-92a-2-5p ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-5589-5p ; hsa-mir-6716-5p ; hsa-mir-4731-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-1180-5p ; hsa-mir-1245b-3p ; hsa-mir-1245b-5p ; hsa-mir-1295b-3p ; hsa-mir-153-3p ; hsa-mir-2682-5p ; hsa-mir-3142 ; hsa-mir-34b-5p ; hsa-mir-3714 ; hsa-mir-3922-5p ; hsa-mir-3937 ; hsa-mir-3942-3p ; hsa-mir-449c-5p ; hsa-mir-5100 ; hsa-mir-561-5p ; hsa-mir-6500-3p ; hsa-mir-7114-3p
Nearest miRNA
hsa-mir-1183/Upstream/97054; hsa-mir-10399/Downstream/673782;
Nearest TSS
ENST00000635602/Upstream/633; ENST00000478411/Downstream/168;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/6836, chr7-CpG: 25/Downstream/12104
Upstream sequence
aggcatgtgccaccacgcctggctaatttttgtatttttagtagagacggtttcaccatgttggtcaggctggtctcgaactcttgatctctggtgatcc
Downstream sequence
acccgcctcatcctcccaaaatgctgggattacaggcgtgagccactgtgcccggccCAGGCTGTGGTTTTTAACCTGTGAAAGTTTGTCCAGCTTCCTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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