Basic Information
VIS ID
TVIS44003229
Fusion event
HTLV-1-TMX3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
66359302/68692065 (Hg38)
End
66359302/68692065 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18C
Target gene
TMX3
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-93-5p ; hsa-mir-877-5p ; hsa-mir-30c-2-3p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-3146 ; hsa-mir-3129-3p ; hsa-mir-5583-5p ; hsa-mir-497-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548t-3p ; hsa-mir-548as-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1-2/Upstream/1610379; hsa-mir-548av/Downstream/4161256;
Nearest TSS
ENST00000575820/Upstream/712; ENST00000582077/Downstream/8358;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1175329, chr18-CpG: 67/Downstream/22632
Upstream sequence
GCATGTTAATACTGAAAATAATGACAAATAAGTAAATGAGTAGATAATGAAGTAAAATAACAATAAAATAAAGACAGTTATCCTGGAAAAATTAAAAAGG
Downstream sequence
GAGGGAGGCACATCTCAGGGGAGAGAAAATAATACAGAATTATTTGGTTACATTACTATTAAAAAATGATATAGCACTATGAAAATAACAATTTTAAGGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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