Basic Information
VIS ID
TVIS44003240
Fusion event
HTLV-1-PTER integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
16508936/16466937 (Hg38)
End
16508936/16466937 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTER
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-29c-5p
Nearest miRNA
hsa-mir-1265/Upstream/2030276; hsa-mir-107/Downstream/1378170;
Nearest TSS
ENST00000439456/Upstream/29953; ENST00000485788/Downstream/17398;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/29633, chr10-CpG: 195/Downstream/52668
Upstream sequence
AAAAATTAAACGGCCTTAGCAAGAAATTCCTGAGGATGGTCTATACATTTAAAACATTTACCTAAGAGCCATTATCCAGTTTTACTTCTTATAAAGGAAG
Downstream sequence
ACCTATGGCCATGAGTCACTTGCAGTAACTTTACTAAGTATTTTTAGTTTTCTGATTTTCAGTTGACTTCCACCAATGCAGATAGGAAATGTCTTTGGAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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