Basic Information
VIS ID
TVIS44003242
Fusion event
HTLV-1-OR9Q1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
57873247/58105775 (Hg38)
End
57873247/58105775 (Hg38)
Orient
+
Location type
Intronic
Target gene
OR9Q1
miRNAs that regulate target gene
hsa-mir-876-3p ; hsa-mir-5087 ; hsa-mir-4765 ; hsa-mir-1236-5p ; hsa-mir-3613-3p ; hsa-mir-2355-3p ; hsa-mir-607 ; hsa-mir-676-3p ; hsa-mir-3671 ; hsa-mir-4775 ; hsa-mir-668-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4762-5p ; hsa-mir-501-5p ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-129-2/Upstream/464489; hsa-let-7a-2/Downstream/1489302;
Nearest TSS
ENST00000527297/Upstream/45637; ENST00000612174/Downstream/13669;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/352494, chr11-CpG: 132/Downstream/472425
Upstream sequence
gcttctataagtttaaatattttagatccctcataaaagtggaattatacagtattttctgtctgtgacttatttgactaagcatatgtcttccaggttc
Downstream sequence
atcatcttgtagcaaatggtaaaatttccagtttaaggctgactaatattctgtttttttgtctataccacatttggtttacccattctgttgatggatg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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