Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene458894104592932346121178459933564599610546000974460029284598253645984019459990054600026545964449459655164599738745998362460036014600380146005294
Basic Information
VIS ID
TVIS44003244
Fusion event
HTLV-1-PHF21A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46026845/46005294 (Hg38)
End
46026845/46005294 (Hg38)
Orient
+
Location type
Intronic
Target gene
PHF21A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-221-3p ; hsa-mir-548c-3p ; hsa-mir-7855-5p ; hsa-mir-216a-5p ; hsa-mir-129-5p ; hsa-mir-1909-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4468 ; hsa-mir-6081 ; hsa-mir-6132 ; hsa-mir-6722-3p ; hsa-mir-6754-5p ; hsa-mir-6836-5p ; hsa-mir-759
Nearest miRNA
hsa-mir-129-2/Upstream/313518; hsa-let-7a-2/Downstream/371108;
Nearest TSS
ENST00000527297/Upstream/33925; ENST00000528480/Downstream/21784;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/82072, chr11-CpG: 65/Downstream/114534
Upstream sequence
gagcactgacgtgatgccacaactggaaaacttcacacctgacctcaagtgatagatcatagtcaacatgcagtcaaaactttgtttcatgtacaaaatg
Downstream sequence
atgtaaaatattgtataaaattTATACAAATTTatgcttgggaccagaagtgtttcagattttgagatttttcagactgtagaatatttgcaCAATATAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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