Basic Information
VIS ID
TVIS44003251
Fusion event
HTLV-1-INSR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
7179885/7179874 (Hg38)
End
7179885/7179874 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
INSR
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-195-5p ; hsa-mir-7108-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-1227/Upstream/443096; hsa-let-7e/Downstream/437565;
Nearest TSS
ENST00000633603/Upstream/11896; ENST00000576789/Downstream/113992;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/36776, chr19-CpG: 27/Downstream/17230
Upstream sequence
CATGAGTGAACAAAGCAGATAATATGCTTTCCCAgtgggaaattataaatgaccatgagttctttgcagcctctcccaccaagaagtggagtctatgttc
Downstream sequence
ccacctgttgaatctgggcttggccatatggcttgctttggccaatggaatatttgcaaacgtgatacaagctgaggcttgaaaagcacttgaacattga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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