Basic Information
VIS ID
TVIS44003252
Fusion event
HTLV-1-AXL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
41747685/41241780 (Hg38)
End
41747685/41241780 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
AXL
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-34a-5p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-122-5p ; hsa-mir-6818-3p ; hsa-mir-4684-5p ; hsa-mir-593-3p ; hsa-mir-5699-3p ; hsa-mir-6895-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-3163 ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-548c-3p ; hsa-mir-34c-5p
Nearest miRNA
hsa-mir-10395/Upstream/871873; hsa-let-7e/Downstream/627847;
Nearest TSS
ENST00000633603/Upstream/15025; ENST00000595336/Downstream/20716;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/15120, chr19-CpG: 22/Downstream/21530
Nearest cancer related gene
AXL(OG, No orient, 0)
Upstream sequence
aagaatacaaaaattagctgggcatggtggtgcacacctgtaatcccagctacttagaagctgaggcaggagatttgcttgaaactgggaggcagaggtt
Downstream sequence
gcaatgagctgagaccgggccactgcactccagcctgggtgaaagagtgagaccctgtctcaaaaaacaaacaaacaaaaaaagagacaaaGAAAACCCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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