Basic Information
VIS ID
TVIS44003260
Fusion event
HTLV-1-RASA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
86577349/87281532 (Hg38)
End
86577349/87281532 (Hg38)
Orient
+
Location type
Intronic
Target gene
RASA1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-132-3p ; hsa-mir-31-5p ; hsa-mir-214-3p ; hsa-mir-30c-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-96-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-10397/Upstream/166578; hsa-mir-103a-1/Downstream/1385321;
Nearest TSS
ENST00000502646/Upstream/12588; ENST00000509953/Downstream/56440;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/13735, chr5-CpG: 55/Downstream/130947
Upstream sequence
ataatagctatcctagtgggtgtgaagtagtaactggttttgatttgcattttcctaagattagtgctgttgagcatcttttcatgtgcttattggccat
Downstream sequence
ttatatatatatcttttttttgaagaaatgtctgttgcccatttttgtttttgtttttgtttttttgagacggaggcttgttctgttgcccaggctggag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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