Basic Information
VIS ID
TVIS44003263
Fusion event
HTLV-1-AUTS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
69608717/70143731 (Hg38)
End
69608717/70143731 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3029334; hsa-mir-10399/Downstream/1163941;
Nearest TSS
ENST00000635602/Upstream/9175; ENST00000475660/Downstream/173185;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/543680, chr7-CpG: 64/Downstream/452117
Upstream sequence
GGATGAATAAAAACAAACAAAAAACATTTCGGTCTCCATTGGCGACTCCCTGGTAATAAATCCAGATGTAGGGATTGTGGCTGTTTTCAAGTAGAAACAT
Downstream sequence
TGCCAAAGGTGATGACTGTCTATTAGGGCTTGTAAACTGTAATATAATCACAGATTTGGAATGGAGTGGTGAAGCCAGATAATTGCAGTGTTTCCTGTCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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