Basic Information
VIS ID
TVIS44003266
Fusion event
HTLV-1-ZFAND5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
74973912/72358996 (Hg38)
End
74973912/72358996 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZFAND5
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-19b-3p ; hsa-mir-18a-5p ; hsa-mir-769-3p ; hsa-mir-320a ; hsa-mir-15b-5p ; hsa-let-7e-5p ; hsa-mir-455-5p ; hsa-mir-10a-5p ; hsa-mir-222-3p ; hsa-mir-496 ; hsa-mir-4742-3p ; hsa-mir-216b-5p ; hsa-mir-7158-3p ; hsa-mir-4517 ; hsa-mir-19a-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-4293 ; hsa-mir-4433a-3p ; hsa-mir-4434 ; hsa-mir-4459 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-4738-3p ; hsa-mir-4802-3p ; hsa-mir-548g-3p ; hsa-mir-5703
Nearest miRNA
hsa-mir-101-2/Upstream/1548912; hsa-let-7a-1/Downstream/11610752;
Nearest TSS
ENST00000422679/Upstream/53479; ENST00000643676/Downstream/1289;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/209009, chr9-CpG: 176/Downstream/5233
Upstream sequence
GTTGTGCTATATAAGCAAAGTTTCCAAAGTCACCATATCTCATGAAAACCAAAATGCCTTTCCACACTGAGTTTCAAACTCCCACAAAATATGATAGGAA
Downstream sequence
TATTGTACTTCAAATAAGTTCTAGTGTTCAAATATGTTGTTCTACTTAAAAGTTTTCCACAACATTGACAATATCAAAACTAAAGTTACTGCTTTTGGTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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