Basic Information
VIS ID
TVIS44003287
Fusion event
HTLV-1-MLC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50507097/50068668 (Hg38)
End
50507097/50068668 (Hg38)
Orient
-
Location type
Intronic
Target gene
MLC1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7a-3/Upstream/105729; hsa-mir-12114/Downstream/338774;
Nearest TSS
ENST00000624155/Upstream/11733; ENST00000475190/Downstream/4147;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/9704, chr22-CpG: 25/Downstream/8044
Upstream sequence
GCGGGTTGCAGGACCACGGCCGGAGCCTGGGAGCCCAGGACAGCGGGCGTGGCCAGGGCTGGGGGGGCGGGCATGGCCGGGCACTCATGGGCATAGTCCC
Downstream sequence
AAGCTGGTTCCCTGCATGACTCCTGCTGAAACCTCTGCCttttcttttttctttttctttttttttttttttttttttgagacaagtctcgctgtgtcgc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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