Basic Information
VIS ID
TVIS44003325
Fusion event
HTLV-1-CNTNAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
145887226/146190134 (Hg38)
End
145887226/146190134 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNTNAP2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-10399/Upstream/2807334; hsa-mir-153-2/Downstream/1187883;
Nearest TSS
ENST00000635602/Upstream/72874; ENST00000636600/Downstream/584137;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/73142, chr7-CpG: 33/Downstream/2149268
Nearest cancer related gene
CNTNAP2(TSG, No orient, 0)
Upstream sequence
CACAGACACTAAAGACAGCACTCTGACTTATAATATGTCAGGTAATAACGGAGATATACTTCAAAGAAGCGATTTCCTTACTGACCCTTGGTAAGAACCC
Downstream sequence
AGGAAAATGATGCAAACCTCATGCGTTCGTTTGTTAATTAGGAGACTGAACATTCATTTCTACTGCCTTTTATATGTGCAGGAAGGCTTCTGGCTCTGGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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