Basic Information
VIS ID
TVIS44003326
Fusion event
HTLV-1-RAB2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
61533751/60621192 (Hg38)
End
61533751/60621192 (Hg38)
Orient
+
Location type
UTR3
Target gene
RAB2A
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-320a ; hsa-mir-142-3p ; hsa-mir-186-5p ; hsa-mir-765 ; hsa-mir-3174 ; hsa-mir-3150b-3p ; hsa-mir-4459 ; hsa-mir-4784 ; hsa-mir-6507-5p ; hsa-mir-6732-5p ; hsa-mir-6752-5p ; hsa-mir-6842-5p ; hsa-mir-6869-5p ; hsa-mir-7110-5p ; hsa-mir-4663 ; hsa-mir-4722-5p ; hsa-mir-4468 ; hsa-mir-6787-3p ; hsa-mir-1207-3p ; hsa-mir-4747-3p ; hsa-mir-6165 ; hsa-mir-3147 ; hsa-mir-6721-5p
Nearest miRNA
hsa-mir-124-1/Upstream/17724917; hsa-mir-10400/Downstream/1093596;
Nearest TSS
ENST00000518652/Upstream/29502; ENST00000373384/Downstream/11579;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/103578, chr8-CpG: 127/Downstream/30453
Upstream sequence
TTGTGTAGTTAGGTTTCCCAACATCTGTGGTTACCTAATGTTTAATATTATAGAACTGTCCTCAGAAACTTTGTCAATTTTCACGGCTATAAGGAAACAG
Downstream sequence
AAGGACTCTTTTAATTCTGTATTTATCATTTACTTTCTGTATATATAGTTTAATAACCTGCTTGGGTGTAATTTGCCAAGCTTGAATTCTTTAATGCATT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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