Basic Information
VIS ID
TVIS44003337
Fusion event
HTLV-1-USP28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
113734840/113864118 (Hg38)
End
113734840/113864118 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11G
Target gene
USP28
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-181a-5p ; hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-221-3p ; hsa-mir-363-3p ; hsa-mir-340-5p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-3163 ; hsa-mir-5003-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-5589-3p ; hsa-mir-20a-3p ; hsa-mir-4729 ; hsa-mir-4668-3p ; hsa-mir-137 ; hsa-mir-153-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-3940-5p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-let-7g-3p ; hsa-mir-129-5p ; hsa-mir-493-5p
Nearest miRNA
hsa-mir-10392/Upstream/414030; hsa-let-7a-2/Downstream/4779882;
Nearest TSS
ENST00000527297/Upstream/30566; ENST00000543092/Downstream/11378;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/73794, chr11-CpG: 103/Downstream/10976
Upstream sequence
acctgaggtcaggagtttgagaccagcctggccaacatggtgaaacccccatctctactaaaaatacaaaaaattagccaggcatggtggcatgtgcctg
Downstream sequence
tagtcccagctactcgggaggctgaggcgggagaatcccttgaactccagaggtggaggctgcagtgagccaagatctcaccactgcactccagcctggg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate