Basic Information
VIS ID
TVIS44003338
Fusion event
HTLV-1-KIRREL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
126381453/126511558 (Hg38)
End
126381453/126511558 (Hg38)
Orient
-
Location type
Intronic
Target gene
KIRREL3
miRNAs that regulate target gene
hsa-mir-218-5p
Nearest miRNA
hsa-let-7a-2/Upstream/3130046; hsa-mir-3167/Downstream/476900;
Nearest TSS
ENST00000527297/Upstream/70676; ENST00000548204/Downstream/32389;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/94583, chr11-CpG: 27/Downstream/488772
Upstream sequence
GCTGTGGCCATTCCCACTCCAAAGGCAGCAATGCATCTTTCCTCTGCAGGACACTGACCATAGCTGTTAGTCTTGGCTCCCGGCTCATGGGCATTGCGTC
Downstream sequence
TTCTGCTTCTGTGGTGTCCTATCCTGCCCCGAAACAGTGGGGGCTCCCTTAGGCTCTGGCCCCTGCCAATCTTCCAGGACCTCTCTTTCTCTCCAGGCTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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