Basic Information
VIS ID
TVIS44003341
Fusion event
HTLV-1-ZNF664-RFLNA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
124534438/124049891 (Hg38)
End
124534438/124049891 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ZNF664-RFLNA
Nearest miRNA
hsa-let-7i/Upstream/513357; hsa-mir-3612/Downstream/287290;
Nearest TSS
ENST00000382841/Upstream/52113; ENST00000621669/Downstream/35870;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/75710, chr12-CpG: 103/Downstream/244992
Upstream sequence
TCGTCTCTCTTAGAAAGGTAGGATGACTGGAAGATTCTCCTGAAAGGTACAGGTGAAGGTGAAATAGCAGATATGGGGCTCATGGCCTGTGACAATGACA
Downstream sequence
ACGATGGCATTGATAGCATCAGCTGCCTTTGGTCAAGCTCCTGCCATTAGCCAGCTGCTGGGCCATGCACCCTCCGTGTGCTCTTGATGAAGGTCCCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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