Basic Information
VIS ID
TVIS44003348
Fusion event
HTLV-1-METTL23 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
74729431/76733349 (Hg38)
End
74729431/76733349 (Hg38)
Orient
-
Location type
Exonic
Target gene
METTL23
miRNAs that regulate target gene
hsa-mir-671-5p ; hsa-mir-99a-5p
Nearest miRNA
hsa-mir-10226/Upstream/635273; hsa-mir-1250/Downstream/3101;
Nearest TSS
ENST00000595228/Upstream/371; ENST00000591864/Downstream/2312;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/6011, chr17-CpG: 221/Downstream/3036
Upstream sequence
GTGATGCTATATGAAAATCTATTCATAAATCCTTTCTCCTCAGATTTTGAAGACATTTTGGCTACAATATATTTTTTGATGCACAAGAATCCCAAGGTCC
Downstream sequence
AATTGTGGTCTACTTATCAAGTTAGGAGGCAAGTATGGATGACCCTTACTTTTTATATGTAACTTAAGCCTTACTCTACCCTACCCATGCGATACATAAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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