Basic Information
VIS ID
TVIS44003358
Fusion event
HTLV-1-chr21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17083530/15711211 (Hg38)
End
17083530/15711211 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA21A
Nearest miRNA
hsa-mir-10396a/Upstream/1986937; hsa-let-7c/Downstream/827878;
Nearest TSS
ENST00000624081/Upstream/83869; ENST00000464435/Downstream/18814;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/645668, chr21-CpG: 123/Downstream/18323
Nearby gene
USP25(+18814) ;
Upstream sequence
gtttctctaaagaagacacataagtggtcaatgagtatatgaaaaagtgatgctcaacatcactaatcatcagaaaagaatcaaaCAGAACTTACATATA
Downstream sequence
TTTTTAAATATTGAATTTCCACATGATGTTTCTCAGAAAAGGGAGTTCCCGTTTTAAAAGTAGTTTTCAAAATATTGAAAACAAATAATAGACAACATAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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